SAAMBE (Single Amino Acid Mutation related change of Binding Energy) method addresses the demand for computational tools of predicting the effect of single amino acid substitution on the binding free energy of protein complexes. It is based on the fast (<< 1 minute) modified MM-PBSA protocol that is successfully tested and optimized for more than thousand experimental data points.
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SAAMBE: Webserver to Predict the Charge of Binding Free Energy Caused by Amino Acids Mutations.
Petukh M, Dai L, Alexov E.
Int J Mol Sci. 2016 Apr 12;17(4). pii: E547.