RVD is a standalone algorithm for ultrasensitive rare single nucleotide variant detection using next-generation sequencing. The RVD program takes BAM files of deep sequencing reads in as input. Using a Beta-Binomial model, the algorithm estimates the error rate at each base position in the reference sequence.
- MacOsX / Linux
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RVD: a command-line program for ultrasensitive rare single nucleotide variant detection using targeted next-generation DNA resequencing.
Cushing A, Flaherty P, Hopmans E, Bell JM, Ji HP.
BMC Res Notes. 2013 May 23;6:206.