ROADTRIPS is a C program that performs single-SNP, case-control association testing in samples with partially or completely unknown population and pedigree structure.ROADTRIPS uses an empirical covariance matrix calculated from genomewide SNP data to correct for unknown population and pedigree structure, while maintaining high power by taking advantage of known pedigree information when it is available. The program is applicable to association studies with completely general combinations of related and unrelated individuals. Analysis can be performed genomewide (currently just for autosomes).
Timothy Thornton and Mary Sara McPeek
- Linux / Windows / MacOsX
- C Compier
:: MORE INFORMATION
Thornton T., McPeek M. S.
“ROADTRIPS: Case-Control Association Testing with Partially or Completely Unknown Population and Pedigree Structure” (2010)
American Journal of Human Genetics, vol 86, pp. 172-184.