R’MES is a set of C++ programs devoted to the detection of motifs with an exceptional frequency in sequences (DNA, protein or other).The main question R’MES addresses is “does this motif occur in that biological sequence with an expected frequency?” In other words, can we observe it so many times, or so few times, just by chance? Usually, when the answer is no, such a motif is a candidate to have a particular biological meaning; only a candidate: statistical significance is not equivalent to biological significance.
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Schbath, S. and Hoebeke, M. (2011).
R’MES: a tool to find motifs with a significantly unexpected frequency in biological sequences.
In Advances in genomic sequence analysis and pattern discovery (L. Elnitski, O. Piontkivska, and L. Welch, eds.). Science, Engineering, and Biology Informatics, vol. 7. World Scientific.