RazerS is a tool for mapping millions of short genomic reads onto a reference genome. It was designed with focus on mapping next-generation sequencing reads onto whole DNA genomes. RazerS searches for matches of reads with a percent identity above a given threshold, whereby it detects matches with mismatches as well as gaps.
RazerS uses a k-mer index of all reads and counts common k-mers of reads and the reference genome in parallelograms. Each parallelogram with a k-mer count above a certain threshold triggers a verification. On success, the genomic subsequence and the read number are stored and written to the output file.
- Linux / Mac / Windows
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RazerS – Fast Read Mapping with Sensitivity Control
David Weese, Anne-Katrin Emde, Tobias Rausch, Andreas Döring, and Knut Reinert
Genome Research, Sep 2009, 19: pp. 1646-1654
Bioinformatics. 2012 Oct 15;28(20):2592-9. doi: 10.1093/bioinformatics/bts505.
RazerS 3: faster, fully sensitive read mapping.
Weese D, Holtgrewe M, Reinert K.