Randfold compute the probability that, for a given RNA sequence, the Minimum Free Energy (MFE) of the secondary structure is different from a distribution of MFE computed with random sequences.
:: MORE INFORMATION
Bonnet, E., * Wuyts, J., Rouzé, P., Van de Peer, Y. (2004)
Evidence that microRNA precursors, unlike other non-coding RNAs, have lower folding free energies than random sequences.
Bioinformatics 20, 2911-7