PSOPIA (Prediction Server Of Protein-protein InterActions) is an AODE for predicting protein-protein interactions using three seqeucne based features; (I) sequence similarities to a known interacting protein pair, (II) statistical propensities of domain pairs observed in interacting proteins and (III) a sum of edge weights along the shortest path between homologous proteins in a PPI network.
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BMC Bioinformatics. 2014 Jun 23;15:213. doi: 10.1186/1471-2105-15-213.
Homology-based prediction of interactions between proteins using Averaged One-Dependence Estimators.
Murakami Y, Mizuguchi K.