PSICOV introduces the use of sparse inverse covariance estimation to the problem of protein contact prediction. The method builds on work which had previously demonstrated corrections for phylogenetic and entropic correlation noise and allows accurate discrimination of direct from indirectly coupled mutation correlations in the MSA.
Bioinformatics Group – University College London
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David T. Jones, Daniel W. A. Buchan, Domenico Cozzetto and Massimiliano Pontil
PSICOV: precise structural contact prediction using sparse inverse covariance estimation on large multiple sequence alignments
Bioinformatics (2012) 28 (2): 184-190.