psi-square is a program for searching the space of gene vectors. The program starts with a gene vector, i.e., the set of measurements associated with a gene, and finds similar vectors, derives a probabilistic model of these vectors, then repeats search using this model as a query, and continues to update the model and search again, until convergence. When applied to three different pathway-discovery problems, psi-square was generally more sensitive and sometimes more specific than the ad hoc methods developed for solving each of these problems before.
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Galina Glazko, Michael Coleman and Arcady Mushegian
Similarity searches in genome-wide numerical data sets
Biology Direct 2006, 1:13