The PseKNC (pseudo oligonucleotide composition, or pseudo K-tuple nucleotide composition), can be used to represent a DNA or RNA sequence with a discrete model or vector yet still keep considerable sequence order information, particularly the global or long-range sequence order information, via the physicochemical properties of its constituent oligonucleotides.
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PseKNC: A flexible web server for generating pseudo K-tuple nucleotide composition.
Chen W, Lei TY, Jin DC, Lin H, Chou KC.
Anal Biochem. 2014 Jul 1;456:53-60. doi: 10.1016/j.ab.2014.04.001.