PROSO II is a sequence-based PROtein SOlubility evaluator. PROSO II is a novel machine-learning based method which makes use of new classification methods and growth in experimental data to improve coverage and accuracy of solubility predictions.The prediction is based on a classifier exploiting subtle differences between soluble proteins from TargetDB and the PDB and notoriously insoluble proteins from TargetDB.
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FEBS J. 2012 Jun;279(12):2192-200. doi: 10.1111/j.1742-4658.2012.08603.x. Epub 2012 May 21.
PROSO II–a new method for protein solubility prediction.
Smialowski P, Doose G, Torkler P, Kaufmann S, Frishman D.