The PROM algorithm represents the successful integration of a genome scale transcriptional regulatory network with a biochemically detailed metabolic network, bridging two important classes of systems biology models that have rarely been combined quantitatively.
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A guide to integrating transcriptional regulatory and metabolic networks using PROM (probabilistic regulation of metabolism).
Simeonidis E, Chandrasekaran S, Price ND.
Methods Mol Biol. 2013;985:103-12.