ProDGe (Protein Domain Gene) visualizes existing and suggests novel domaindomain interactions and protein-protein interactions at the domain level. The comprehensive dataset behind ProDGe consists of protein, domain and interaction information for both layers, collected and combined appropriately from UniProt, Pfam, DOMINE and IntAct. Based on known domain interactions, ProDGe suggests novel protein interactions and assigns them to four confidence classes, depending on the reliability of the underlying domain interaction. Furthermore, ProDGe is able to identify potential homologous interaction partners in other species, which is particularly helpful when investigating poorly annotated species.
the Center for Bioinformatics Tübingen (Zentrum für Bioinformatik Tübingen, ZBIT).
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Büchel, Finja, Wrzodek, Clemens, Mittag, Florian, Dr?ger, Andreas, Schr?der, Adrian, and Zell, Andreas.
ProDGe: investigating protein-protein interactions at the domain level.
Nature Precedings (2011)