Predivac implements a method for prediction of CD4+ T-cell epitopes based on the specificity-determining residues (SDRs) approach. SDRs are small set of structurally conserved amino acids in the peptide:protein interaction interface that are responsable for specific recognition events.
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BMC Bioinformatics. 2013 Feb 14;14(1):52. [Epub ahead of print]
PREDIVAC: CD4+ T-cell epitope prediction for vaccine design that covers 95% of HLA class II DR protein diversity.
Oyarzún P, Ellis JJ, Bodén M, Kobe BT.