PRED-SIGNAL is a hidden Markov model method that predicts the presence of the SPs and their cleavage sites and also discriminates such proteins from cytoplasmic and transmembrane ones.
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Protein Eng Des Sel. 2009 Jan;22(1):27-35. doi: 10.1093/protein/gzn064. Epub 2008 Nov 6.
Prediction of signal peptides in archaea.
Bagos PG, Tsirigos KD, Plessas SK, Liakopoulos TD, Hamodrakas SJ.