PON-Diso is a machine learning based prediction method, which is developed using Random Forest classifier on AAIndex features and Evolutionary features. PON-Diso is a method to predict changes in disorder regions contained in protein caused by amino acid substitutions.
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Hum Mutat. 2014 Jul;35(7):794-804. doi: 10.1002/humu.22564. Epub 2014 May 21.
Performance of protein disorder prediction programs on amino acid substitutions.
Ali H1, Urolagin S, Gurarslan Ö, Vihinen M.