PMUT is a web-based tool for the annotation of pathological mutations on proteins. PMUT allows the fast and accurate prediction (~80% success rate in humans) of the pathological character of single point amino acidic mutations based on the use of neural networks. The program also allows the fast scanning of mutational hot spots, which are obtained by three procedures: (1) alanine scanning, (2) massive mutation and (3) genetically accessible mutations.
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Bioinformatics. 2005 Jul 15;21(14):3176-8. Epub 2005 May 6.
PMUT: a web-based tool for the annotation of pathological mutations on proteins.
Ferrer-Costa C, Gelpí JL, Zamakola L, Parraga I, de la Cruz X, Orozco M.