PINTA is a gene prioritization tool that identifies the most promising candidates within a region when only sparse information about the phenotype is available by replacing this knowledge by experimental data on differential gene expression between affected and healthy individuals. Considering the problem from the perspective of a gene/protein network, it assesses the relevance of a candidate gene by considering the level of differential expression in its network neighborhood under the assumption that strong candidates tend to be surrounded by differentially expressed neighbors.
Bioinformatics Research Group, Belgium
- Web Browser
:: MORE INFORMATION
Nucleic Acids Res. 2011 Jul;39(Web Server issue):W334-8. doi: 10.1093/nar/gkr289. Epub 2011 May 20.
PINTA: a web server for network-based gene prioritization from expression data.
Nitsch D, Tranchevent LC, Gon?alves JP, Vogt JK, Madeira SC, Moreau Y.