Phyre2 is a major update to the original Phyre server. As with Phyre, the new system is designed around the idea that you have a protein sequence/gene and want to predict its three-dimensional (3D) structure. Whereas Phyre used a profile-profile alignment algorithm, Phyre2 uses the alignment of hidden Markov models via HHsearch1 to significantly improve accuracy of alignment and detection rate.
Structural Bioinformatics Group, Imperial College
- Web Browser
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The Phyre2 web portal for protein modeling, prediction and analysis.
Kelley LA, Mezulis S, Yates CM, Wass MN, Sternberg MJ.
Nat Protoc. 2015 Jun;10(6):845-58. doi: 10.1038/nprot.2015.053.
Protein structure prediction on the Web: a case study using the Phyre server.
Kelley LA, Sternberg MJ.
Nat Protoc. 2009;4(3):363-71. doi: 10.1038/nprot.2009.2.