PhyloGena is a software tool to facilitate phylogenetic annotation of unknown sequences. It has a user-friendly graphical interface and you will intuitively learn how to use it. You can import 1, 10, 100, 1000? (see below) DNA or protein sequences and the program will search for similar sequences, construct a multiple alignment and subsequently a phylogenetic tree for all of them and show them to you. You can easily manipulate the data sets, add or remove sequences, change parameters etc. This is of great help in identifying the function and phylogenetic affiliation of ORFs and makes annotation of genes or ESTs easier and less error-prone.
- Windows/ Linux / Mac OsX
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Hanekamp K, Bohnebeck U, Beszteri B, Valentin K.
PhyloGena–a user-friendly system for automated phylogenetic annotation of unknown sequences.
Bioinformatics. 2007 Apr 1;23(7):793-801. Epub 2007 Mar 1.