PhyloCOP (phylogeny-based Clusters of Orthologous Proteins) is a customizable program for the assignment of orthologous genes into clusters. PhyloCOP detects transitive orthologous relationships between highly diverse prokaryotic proteins and assigns them into orthologous clusters, simultaneously excluding paralogy. Orthology assignment is based on best BLAST (Basic Local Alignment Search Tool) protein sequence similarity hits between pairs of genomes.
Group Bioinformatics, Heinrich-Heine-Universität Düsseldorf
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