PHDcleav is a webserver to predict Dicer cleavage sites in pre-miRNA. Dicer, an RNase III enzyme, plays vital role in RNA interference pathway, processes both pre-miRNAs (precursor microRNAs) and double-stranded (ds) RNAs to generate effector molecules. Thus it is very important to know true Dicer processing sites in the pre-miRNA molecules to understand the RNA interference pathway.
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BMC Bioinformatics. 2013;14 Suppl 14:S9. doi: 10.1186/1471-2105-14-S14-S9. Epub 2013 Oct 9.
PHDcleav: a SVM based method for predicting human Dicer cleavage sites using sequence and secondary structure of miRNA precursors.
Ahmed F, Kaundal R, Raghava GP.