pGenTHREADER and pDomTHREADER is two improved versions of the GenTHREADER protocol for recognizing and aligning protein sequences and demonstrate their application to structure prediction and superfamily discrimination. The two versions use the same core alignment algorithm and in both cases accept features derived from common inputs: protein sequence profiles and structural information. However, the representation and combinations of these features differ between the methods and scoring and confidence values have been tuned to optimize performance in each application domain.
Bioinformatics Group – University College London
:: MORE INFORMATION
Lobley, A., Sadowski, M.I. & Jones, D.T. (2009)
pGenTHREADER and pDomTHREADER:New Methods For Improved Protein Fold Recognition and Superfamily Discrimination.
Bioinformatics. 25, 1761-1767.