Apr 152013
 

NRPSpredictor2 20111113

:: DESCRIPTION

NRPSpredictor, based on Transductive Support Vector Machines (TSVMs) was built on these 34 active site residues to predict A-domain specificity. The products of many bacterial non-ribosomal peptide synthetases (NRPS) are highly important secondary metabolites, including vancomycin and other antibiotics. The ability to predict substrate specificity of newly detected NRPS Adenylation (A-) domains by genome sequencing efforts is of great importance to identify and annotate new gene clusters that produce secondary metabolites. Prediction of A-domain specificity based on the sequence alone can be achieved through sequence signatures or, more accurately, through machine learning methods.

::DEVELOPER

APPLIED BIOINFORMATICS GROUP

:: SCREENSHOTS

N/A

:: REQUIREMENTS

:: DOWNLOAD

 NRPSpredictor2

:: MORE INFORMATION

Citation

Röttig et al.
NRPSpredictor2—a web server for predicting NRPS adenylation domain specificity
Nucleic Acids Research 39 (suppl 2): W362-W367 (2011)

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