NMFF (Normal Mode Flexible Fitting) is an evolving package of programs and methods that enable the flexible multi-resolution fitting of large atomically detailed structures into electron density maps from cryoEM, tomography and related lower resolution methods.The theory and methods behind NMFF are based on searching along a few lowest frequency normal mode vectors, constructed from a multi-resolution elastic network representation of the atomic structure of interest, to maximize the correlation between the computed electron density for the flexible model and the experimental density.
NIH Research Resource Center for the Development of Multiscale Modeling Tools for Structural Biology
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F Tama, O Miyashita and CL Brooks, III. Flexible multi-scale fitting of atomic structures into low-resolution electron density maps with elastic network normal mode analysis.
Journal of Molecular Biology, 2004, 337 (4), 985-99.