NMF (Non-negative Matrix Factorization), an algorithm based on decomposition-by-parts, recovers meaningful information without supervision. Coupled with a novel model selection mechanism, and efficiently implemented in Matlab, NMF is a powerful method for identification of context-dependent patterns in complex biological systems.
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Jean-Philippe Brunet, Pablo Tamayo, Todd Golub, Jill Mesirov
Metagenes and molecular pattern discovery using matrix factorization
Proc. Natl. Acad. Sci. USA 2004 101: 4164-4169