NetEffects analyse the effects of perturbations to specific pathway components on the rest of the pathway, and especially the biological processes it controls. Two different ways of studying each pathway are provided: querying it by up- or down-regulating specific components, or importing gene expression data and phenotype information (lifespan extension/reduction) and inferring the effects on the pathway.
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Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing.
Papatheodorou I, Ziehm M, Wieser D, Alic N, Partridge L, Thornton JM.
PLoS One. 2012;7(12):e50881. doi: 10.1371/journal.pone.0050881