NetCTL predicts CTL epitopes in protein sequences. NetCTL expands the MHC class I binding predicition to 12 MHC supertypes including the supertypes A26 and B39. The accuracy of the MHC class I peptide binding affinity is significantly improved compared to the earlier version. Also the prediction of proteasonal cleavage has been improved and is now identical to the predictions obtained by the NetChop-3.0 server. The updated version has been trained on a set of 886 known MHC class I ligands.
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Large-scale validation of methods for cytotoxic T-lymphocyte epitope prediction.
Larsen MV, Lundegaard C, Lamberth K, Buus S, Lund O, Nielsen M.
BMC Bioinformatics. Oct 31;8:424. 2007