MutationAssessor server predicts the functional impact of amino-acid substitutions in proteins, such as mutations discovered in cancer or missense polymorphisms. The functional impact is assessed based on evolutionary conservation of the affected amino acid in protein homologs.
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Reva B, Antipin Y, Sander C.
Nucl. Acids Res. (2011) 39 (17): e118. doi: 10.1093/nar/gkr407
“Predicting the Functional Impact of Protein Mutations: Application to Cancer Genomics”