MultiGeneBlast is an open source tool for identification of homologs of multigene modules such as operons and gene clusters. It is based on a reformatting of the FASTA headers of NCBI GenBank protein entries, using which it can track down their source nucleotide and coordinates.
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Mol Biol Evol. 2013 May;30(5):1218-23. doi: 10.1093/molbev/mst025. Epub 2013 Feb 14.
Detecting sequence homology at the gene cluster level with MultiGeneBlast.
Medema MH1, Takano E, Breitling R.