Multi-Dendrix is an algorithm for the simultaneous discovery of multiple driver pathways using only somatic mutation data from a cohort of samples. Multi-Dendrix uses an integer linear program to identify pathway sets such that each pathway contains genes with approximately mutually exclusive mutations and high coverage of the sample set.
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M.D.M. Leiserson, D. Blokh, R. Sharan, B.J. Raphael. (2013)
Simultaneous Identification of Multiple Driver Pathways in Cancer.
PLoS Comp Bio, 9(5):e1003054