Mtreemix is a software package to estimate mixture models of mutagenetic trees from observed cross-sectional data. Mutagenetic tree mixtures are probabilistic models that have been designed to describe evolutionary processes that are characterized by the accumulation of genetic changes. Mtreemix has been applied to model the development of drug resistance-associated mutations in the HIV genome and the accumulation of chromosomal gains and losses in tumor development.
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Beerenwinkel, N.; Rahnenführer, J.; Kaiser, R.; Hoffmann, D.; Selbig, J.; Lengauer, T.,
Mtreemix: a software package for learning and using mixture models of mutagenetic trees.
Bioinformatics 2005, 21 (9), 2106-7.