MSNS estimates effects of non-specific hybridization included in observed probe intensity. It assumes that the amounts of cross-hybridization on a probe can be estimated as an ensemble of a diverse of fragments which randomly hybridize with the probe non-specifically. This package provids functions for the estimation of non-specific hybridization and optimization of parameters used in the model.
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Bioinformatics. 2009 Jan 1;25(1):36-41. doi: 10.1093/bioinformatics/btn570. Epub 2008 Oct 31.
Model-based analysis of non-specific binding for background correction of high-density oligonucleotide microarrays.
Furusawa C1, Ono N, Suzuki S, Agata T, Shimizu H, Yomo T.