Dec 042013
 

MixHMM 20100415

:: DESCRIPTION

MixHMM is a novel hidden Markov model using hidden states based on chromosomal structural aberrations. MixHMM allows CNV detection for copy numbers up to 7 and allows more complete and accurate description of other forms of allelic imbalance, such as increased copy number LOH or imbalanced amplifications. MixHMM also incorporates a novel sample mixing model that allows detection of tumor CNV events in heterogeneous tumor samples, where cancer cells are mixed with a proportion of stromal cells.

::DEVELOPER

MixHMM team

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows/Linux/MacOsX
  • Python

:: DOWNLOAD

 MixHMM

:: MORE INFORMATION

Citation

PLoS One. 2010 Jun 1;5(6):e10909. doi: 10.1371/journal.pone.0010909.
MixHMM: inferring copy number variation and allelic imbalance using SNP arrays and tumor samples mixed with stromal cells.
Liu Z, Li A, Schulz V, Chen M, Tuck D.

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