miRTar /miRTarBase 4.5
miRTar (MicroRNA Target prediction) is a tool that enables biologists easily to identify the biological functions and regulatory relationships between a group of known/putative miRNAs and protein coding genes. It also provides perspective of information on the miRNA targets on alternatively spliced transcripts.
As a database, miRTarBase has accumulated more than fifty thousand miRNA-target interactions (MTIs), which are collected by manually surveying pertinent literature after data mining of the text systematically to filter research articles related to functional studies of miRNAs. Generally, the collected MTIs are validated experimentally by reporter assay, western blot, microarray and next-generation sequencing experiments. While containing the largest amount of validated MTIs, the miRTarBase provides the most updated collection by comparing with other similar, previously developed databases.
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BMC Bioinformatics. 2011 Jul 26;12:300. doi: 10.1186/1471-2105-12-300.
miRTar: an integrated system for identifying miRNA-target interactions in human.
Hsu JB, Chiu CM, Hsu SD, Huang WY, Chien CH, Lee TY, Huang HD.
Nucleic Acids Res. 2011 Jan;39(Database issue):D163-9. doi: 10.1093/nar/gkq1107.
miRTarBase: a database curates experimentally validated microRNA-target interactions.
Hsu SD, Lin FM, Wu WY, Liang C, Huang WC, Chan WL, Tsai WT, Chen GZ, Lee CJ, Chiu CM, Chien CH, Wu MC, Huang CY, Tsou AP, Huang HD.