MGRA is a software for reconstruction of phylogenetic trees as well as ancestral genomes and applied it to study the rearrangement history of seven mammalian genomes: human, chimpanzee, macaque, mouse, rat, dog, and opossum. MGRA relies on the new notion of the multiple breakpoint graphs to overcome some limitations of the existing approaches to ancestral genome reconstructions. In particular, we applied \MGRA to analyze the primate–rodent–carnivore controversy in mammalian phylogeny, i.e., the alternative between the primate–rodent and primate–carnivore clades. MGRA provided the rearrangement-based evidence, albeit limited, for the primate–carnivore clade as opposed to the currently favored primate–rodent clade.
- C++ Compiler
:: MORE INFORMATION
Max Alekseyev, Pavel Pevzner
“Breakpoint Graphs and Ancestral Genome Reconstructions.”
Genome Res. 2009 May;19(5):943-57. Epub 2009 Feb 13.