METREE is intended to find the minimum evolution (ME) tree that has the smallest value of the sum of branch lengths (S) for a set of sequences, identify a set of trees whose S are not significantly different from that of the ME tree, and print out the resulting trees in a publishable form. The branch lengths for each topology are estimated by the ordinary least-squares method from a matrix of evolutionary distances.
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Comput Appl Biosci. 1994 Jul;10(4):409-12.
METREE: a program package for inferring and testing minimum-evolution trees.
Rzhetsky A, Nei M.