METASOFT is a meta-analysis software tool for genome-wide association studies that provides the following methods
Fixed Effects model (FE): Fixed effects model based on inverse-variance-weighted effect size.
Random Effects model (RE): Conventional random effects model based on inverse-variance-weighted effect size. Heterogeneity is estimated using DerSimonian-Laird method.
Han and Eskin’s Random Effects model (RE2): Random effects model that increases power under heterogeneity.
Binary Effects model (BE): Random effects model assuming that the effects either exist or not in the studies.
- Linux / Mac OsX / Windows
:: MORE INFORMATION
Buhm Han and Eleazar Eskin,
“Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies”,
The American Journal of Human Genetics (2011) 88, 586-598.