MDR-PDT merges the MDR method with the genotype-Pedigree Disequilibrium Test (geno-PDT). MDR-PDT allows identification of single-locus effects or joint effects of multiple loci in families of diverse structure. We present simulations to demonstrate the validity of the test and evaluate its power. To examine its applicability to real data, we applied the MDR-PDT to data from candidate genes for Alzheimer disease (AD) in a large family dataset. These results show the utility of the MDR-PDT for understanding the genetics of complex diseases.
- Windows / Linux / MacOsX
:: MORE INFORMATION
Martin, Ritchie, Hahn, Kang, Moore (2006),
“A novel method to identify gene-gene effects in nuclear families: the MDR-PDT“,
Genetic Epidemiology, 30:111-123.