The software MASS performs meta-analysis by combining the score statistics from K independent studies.The two approaches are asymptotically equivalent; however, the latter approach is numerically more stable and statistically more accurate, especially for discrete outcomes and unbalanced data (e.g., rare variants in case-control studies) (Lin and Tang, 2011). Another unique feature of MASS is its ability to perform multivariate meta-analysis.
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Lin DY, Tang ZZ. (2011).
A general framework for detecting disease associations with rare variants in sequencing studies.
The American Journal of Human Genetics, 89:354-367.