LPIA is a computational method for identifying biological pathways as putative sources of transcriptional dysregulation. It looks for statistically signficant evidence of dysregulation in a network of pathways constructed in a manner that explicitly links pathways through their common function in the cell.
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Pham, L., Christadore, L., Schaus, S., and Kolaczyk, E.D. (2011).
Network-based prediction for sources of transcriptional dysregulation via latent pathway identification analysis.
Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1100891108.