Jan 272013
 

LIPED

:: DESCRIPTION

LIPED program (for LIkelihoods in PEDigrees) estimates the recombination fraction by calculating pedigree likelihoods for various assumed values of the recombination fraction. The algorithm is based on Elston and Stewart (1971) with some extensions. Its first application (to the large Alaska pedigree, Schrott et al. 1972) resulted in mild evidence for linkage of familial hypercholesterolemia to the C3 polymorphism (Ott et al 1974), which was later confirmed by various authors. This disease locus (LDLR, previously FH and FHC) is now located on chromosome 19p13.3

::DEVELOPER

Jurg Ott, Ph.D.

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Windows

:: DOWNLOAD

 LIPED

:: MORE INFORMATION

Terwilliger JD, Ott J (1994) Handbook of Human Genetic Linkage. Johns Hopkins University Press, Baltimore

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