LightAssembler is a lightweight assembly algorithm designed to be executed on a desktop machine. It uses a pair of cache oblivious Bloom filters, one holding a uniform sample of g-spaced sequenced k-mers and the other holding k-mers classified as likely correct, using a simple statistical test.
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LightAssembler: fast and memory-efficient assembly algorithm for high-throughput sequencing reads.
El-Metwally S, Zakaria M, Hamza T.
Bioinformatics. 2016 Jul 13. pii: btw470.