LDWP (Linked Region Detection without Pedigree) is a software package for linkage analysis that finds the mutation regions for the case where the input individuals are closely related, but the pedigree is not known. A typical example is that in the pedigree below the individuals in the dotted rectangle are closely related,and the genotype data of them are known, whereas the genotype data of individuals outside the dotted rectangle are not available and even the pedigree may not be clear. LDWP takes the genotype data of the individuals in the dotted rectangle and the diagnoses (diseased or normal) information of each individual in the dotted rectangle as its input, and report the mutation regions.
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IEEE/ACM Trans Comput Biol Bioinform. 2012 Mar-Apr;9(2):499-510. doi: 10.1109/TCBB.2011.134
Mutation Region Detection for Closely Related Individuals without a Known Pedigree Using High-Density Genotype Data.
Ma W, Yang Y, Chen ZZ, Wang L.