LACK addresses whether or not a theme is actually overrepresented in your significant genes list. The program takes a list of significant genes and a list of user-specified search terms, and counts the number of genes which contain one of the search terms. Then, the program takes a random set of genes of the same size as the significant set from a genome annotation file and counts the hits. This process is repeated a user-specified number of times so that statistics regarding the randomness of the frequencies can be calculated. Statistics and histogram data is output to a text file.
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The software is copyrighted under the terms of the GNU General Public License. You can view this license at http://www.gnu.org/licenses/gpl.txt.
If you use LACK, please cite:
Kim CC, Falkow S.
Significance analysis of lexical bias in microarray data.
BMC Bioinformatics. 2003 Apr 3;4(1):12.