KOBAS (KEGG Orthology Based Annotation System) is a web server that annotates an input set of genes with putative pathways and disease relationships based on mapping to genes with known annotations. It allows for both ID mapping and cross-species sequence similarity mapping. It then performs statistical tests to identify statistically significantly enriched pathways and diseases.
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Xie, C., Mao, X., Huang, J., Ding, Y., Wu, J., Dong, S., Kong, L., Gao, G., Li, C. and Wei, L. (2011)
KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases.
Nucleic Acids Res, 39, W316-322