kinfold is a software to analyze kinetic progress curves systematically, and then exhaustively enumerate all possible kinetic models to identify the best fitting kinetic model. Local probes of macromolecular structure are measurements that are sensitive to the environment of a relatively small region within a macromolecule. These include, but are not limited to, NMR deuterium exchange and shift perturbation analysis, Fluorescence Resonance Energy Transfer (FRET), and RNA/DNA protein footprinting. The separate transitions reported by individual probes yield unique insight into folding intermediates. While simultaneous acquisition of many unique local transitions provides a cornucopia of information, creating an accurate global description of folding that remains faithful to local details is very challenging.
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J.S. Martin, K. Simmons, and A. Laederach.
Exhaustive Enumeration of Kinetic Model Topologies for the Analysis of Time-Resolved RNA Folding.