K-Map is a novel and user-friendly web-based program that systematically connects a set of query kinases to kinase inhibitors based on quantitative profiles of the kinase inhibitor activities. Users can use K-Map to find kinase inhibitors for a set of query kinases (obtained from high-throughput “omics” experiments) or to reveal new interactions between kinases and kinase inhibitors for rational drug combination studies.
The Tan Lab, University of Colorado Anschutz Medical Campus
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Bioinformatics. 2014 May 7. [Epub ahead of print]
Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy.
Kim J1, Vasu VT, Mishra R, Singleton KR, Yoo M, Leach SM, Farias-Hesson E, Mason RJ, Kang J, Ramamoorthy P, Kern JA, Heasley LE, Finigan JH, Tan AC.