JET (Joint Evolutionary Trees) is a method designed to detect very different types of interactions of a protein with another protein, ligands, DNA, and RNA. It uses carefully designed sampling method, making sequence analysis more sensitive to the functional and structural importance of individual residues, and a clustering method parametrized on the target structure for the detection of patches on protein surfaces and their extension into predicted interaction sites.
- Linux / MacOsX
- PSI-BLAST from BLAST Toolkit
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Engelen S, Trojan LA, Sacquin-Mora S, Lavery R, Carbone A.
Joint evolutionary trees: a large-scale method to predict protein interfaces based on sequence sampling,
PLoS Comput Biol, 5(1):e1000267, 2009.