JCat (Java Codon Adaptation Tool)presents a simple method to adapt the Codon Usage to most sequenced prokaryotic organisms and selected eukaryotic organisms. The codon adaptation plays a major role in cases where foreign genes are expressed in hosts and the codon usage of the host differs from that of the organism where the gene stems from. Unadapted codons in the host can for example lead to a minor expression rate.
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Grote A, Hiller K, Scheer M, Munch R, Nortemann B, Hempel DC, Jahn D.
JCat: a novel tool to adapt codon usage of a target gene to its potential expression host.
Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W526-31.